Book through our site
—up to 10% cheaper
than Booking.com
Check rooms and rates
From60US$ /night
Check-in
12Dec2025Select date
Check-out
13Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

110 South Interstate Drive, Sikeston, Missouri, United States, MO 63801
-
Near the Sikeston Depot Museum & Gallery
Perfect
5.6
/10

Location

Motel 6 Sikeston is conveniently situated off Interstate 55, just a short drive from popular attractions such as the Sikeston Depot Museum and the historic Bootheel Golf Club. The hotel provides easy access to local dining options, retail establishments, and entertainment venues. Guests can explore the nearby Mississippi River and its scenic parks within minutes.

Accessibility

The hotel offers accessible rooms designed with a focus on convenience for all guests, ensuring a comfortable stay. Each room includes accessible features such as wider doorways, grab bars, and roll-in showers. The well-lit parking lot enhances the ease of access for all visitors.

Pet Policy

Motel 6 Sikeston welcomes pets, allowing travelers to bring their furry companions along for the journey. There are no additional fees for pets, making it a cost-efficient option for pet owners. The hotel features designated pet areas for easy outdoor access.

Rooms

The hotel offers a range of comfortable rooms equipped with modern amenities like flat-screen TVs and air conditioning. Each room features a workstation designed for convenience, allowing guests to catch up on work or plan their day. Select rooms also include additional space options for larger groups or families.

Amenities

The hotel provides essential services including a 24-hour front desk and laundry facilities, ensuring guests can easily manage their needs. An outdoor seasonal pool offers a refreshing option for relaxation during warmer months. Additional vending machines are available, providing quick snacks and beverages.

Highlights

Location: Short drive from Sikeston Depot Museum

Accessibility: Accessible rooms with roll-in showers

Pet Policy: Welcomes pets at no extra fee

Rooms: Flat-screen TVs and workstations

“What stands out here is the pet-friendly policy and the updated, spacious rooms, especially appreciated after a long drive. The location is convenient if you're hauling a trailer, and the staff earns points for being friendly and helpful. While some noise from the freeway can seep in, the value for money makes it a reasonable stopover.”
Hotel logo
James DavidEditor-in-Chief at Cheaphotels
View all

Select your room type

The hotel provides a selection of rooms—doubles, family rooms, and suites—with perks like free cancellation, breakfast options, and great value deals
Double Room
2 persons
28 m² 
2 King Size Beds
Heating
Bathtub
King Suite
2 persons
28 m² 
1 King-size bed
Heating
Bathtub
Standard King Room
2 persons
28 m² 
1 King-size bed
Heating
Bathtub
Standard Double Room
2 persons
28 m² 
2 King Size Beds
Heating
Bathtub
Click button to see more rooms
Show all rooms
Show all roomsLess

Room rates & availability calendar

See the best prices and book your dates today!

Amenities & services

Real traveler stories and honest reviews—no glossy ads, just authentic feedback to guide your booking

General

  • Non-smoking property
  • Free Wi-Fi
  • Parking
  • 24-hour reception
  • Pets allowed

Media

  • Flat-screen TV
  • AM/FM alarm clock
Show more

Location

110 South Interstate Drive, Sikeston, Missouri, United States, MO 63801
Map view
110 South Interstate Drive, Sikeston, Missouri, United States, MO 63801
Explore Sikeston
Nearby Attractions
Top Attractions
Activities
Dining
Entertainment
Malco Sikeston Cinema and Grill
Malco Sikeston Cinema and Grill
10-minute drive
Cinema and dining combined; enjoy the latest films with a full menu. Perfect for a family night out.
Sikeston Depot Museum & Gallery
Sikeston Depot Museum & Gallery
15-minute drive
Local history exhibits and art showcased in a historical train depot. Offers guided tours and free admission days.
Boot Heel Golf Club
10-minute drive
Challenging 18-hole course set in scenic surroundings. A perfect activity for golf enthusiasts.
Sikeston Sports Complex
15-minute drive
Family-friendly sports venue with multiple fields for various activities. A great spot for casual games.
Hiking at LaForge Conservation Area
15-minute drive
Beautiful hiking trails through nature; great for all skill levels. Open year-round with no entrance fees.
Golfing at Boot Heel Golf Club
10-minute drive
18-hole golf course offering rentals. Thrill-seekers can enjoy a day on the greens surrounded by nature.
Relaxation at Sikeston Spa
10-minute drive
Full-service spa with various wellness options. Perfect for those seeking relaxation and rejuvenation.
Lambert's Cafe
5-minute drive
Famous for throwed rolls and generous portions. A casual dining experience with home-style cooking.
El Toro Mexican Grill
5-minute drive
Authentic Mexican cuisine with a vibrant atmosphere. Great for families and offers vegetarian options.
Waffle House
3-minute drive
Classic diner atmosphere with breakfast served all day. Known for its friendly service and quick meals.
Malco Theatre
10-minute drive
Enjoy the latest blockbuster films in a comfortable setting with a full-service snack bar.
Sikeston Knight's of Columbus
10-minute drive
Host to various events and social gatherings. Family-friendly atmosphere with regular community activities.
Getting around town
City Centre
Sikeston9 min  ·  5.5 km
Airports
Cape Girardeau Regional Airport (CGI)65 min  ·  42.9 km
Barkley Regional Airport (PAH)131 min  ·  87.0 km
Looking for early-bird discounts?
Get special discounted rates today!
Check Rates
Property information and rules
Check-in
from 14:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
No internet access available.Wireless internet is available in the entire hotel for free.
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are allowed on request.
Number of rooms:
46
Former name
Motel 6
FAQs
About Motel 6-Sikeston, Mo
What is the check-in and check-out policy at Motel 6-Sikeston, Mo?
Check-in is at 14:00 and check-out is by 11:00.
How far is Motel 6-Sikeston, Mo from the nearest airport?
The nearest airport is Barkley Regional Airport, located 70 km from the property.
What amenities are available in the rooms at Motel 6-Sikeston, Mo?
Rooms are equipped with air conditioning, a flat-screen TV with cable channels, and a private bathroom.
Is parking available at Motel 6-Sikeston, Mo?
On-site parking is available for guests.
Which nearby attractions can visitors explore when staying at Motel 6-Sikeston, Mo?
Guests can visit the Sikeston Depot Museum & Gallery, located 24 km away, and the Malco Sikeston Cinema and Grill, which is 4 km from the hotel.
Does Motel 6-Sikeston, Mo allow pets?
Pets are allowed at the property.
What dining options are near Motel 6-Sikeston, Mo?
Nearby dining options include fast-food restaurants and local diners within a short drive.
What kind of services does Motel 6-Sikeston, Mo provide?
The hotel provides a 24-hour reception, laundry facilities, and free local calls.

Next best alternative

Consider them for your next trip.
Check-in
12Dec2025Select date
Check-out
13Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near Motel 6-Sikeston, Mo
Country Yard Inn Sikeston - Miner Exit 67 On I-55 Beds photo
Mobile-only price

Country Yard Inn Sikeston - Miner Exit 67 On I-55

5.1
Guest rating93 reviews
14m from property
USD 62USD 55
per night
Days Inn And Suites By Wyndham Sikeston Exterior photo
Mobile-only price

Days Inn And Suites By Wyndham Sikeston

7.1
Very good239 reviews
316m from property
USD 74USD 66
per night
Pear Tree Inn Sikeston Exterior photo
Mobile-only price

Pear Tree Inn Sikeston

9.2
Perfect833 reviews
608m from property
USD 90USD 81
per night